It's a grill... brush the grates down every cook, preferably while it's still warm. Drip tray, scrape the gunk off it when it needs it.
Being a pellet grill, dump or vacuum the burn pot every cook. Nothing worse than having a bunch of food prepared only to find the pellets won't light because ash has built up in the firepot.
If you want to spend time cleaning your Q450, clean up the smoke stains around the door areas where the smoke sneaks out.