I never thought of Reno as a destination. As mentioned, Tahoe is nice. The Eastern Sierra (i.e. Owen's Valley), Tuolumne Meadows in Yosemite National Park, Death Valley, are what I would think of as destinations in the, broadly speaking, general area. So it really depends on what you like to do. Nevada is casinos and backcountry. I can pass on the casinos but some of the backcountry is hard to beat, if you like desert, and I do. I have stayed in a lot of casinos visiting Nevada, but mostly just to sleep and maybe catch a buffet, while out hiking or climbing.