I will slice some both ways. I like more chew so with the grain for me, but the GF and a few others like the tenderness of across. I do cut mine in to manageable pieces. say 4-6 inches long. also use cure so I am not that concerned with the fat that is on the pork loin, I trim silver skin and not much else on them except for that thin tail that runs the length it is just a hassle and I cut it off. I do trim up the fat on the whole eyes, if I find eye roasts, most of the time they are already trimmed. I have several different ways to cut mine, but lately I have just been sitting at the table and hand cutting with a knife. I need to find a better knife than what I use. For with the grain I have been wondering about that expensive mandolin I bought a few years ago, maybe a slight freeze and run it across if, not sure how it would work across the grain.