If you grew up 50 miles from Detroit, and visit Detroit several times a year for 'fun'. St Louis is nothing to fear.
Actually I've only been to St Louis once, stayed at a nice hotel down town, took a horse drawn carriage ride around town late at night. All in all , I very much enjoyed that trip. Unfortunately I didn't actually get to any BBQ places.
I did experience some food off a Ole' Hickory smoker , up in Oscoda Michigan. I had a chicken half that was cooked on it. I enjoyed it a great deal, it was a lot more 'smokey' than I can get a chicken on my pellet grill, and it'd been a while since I had a really smokey tasting chicken. Pleasant experience really, If I went back, I'd probably order the chicken again... ( cheap, and was actually pretty good ).