Like I've stated before, I know that I'm a bit weird, but I believe that fat prevents seasoning and smoke from reaching the meat, so I normally trim all visible fat from all my meats. As for Sous Vide, I don't do anything special, I just prepare, (season, inject, marinate, etc.), as if I were going to only smoke, but I smoke at low temps. until IT reaches 120-130° then vacuum pack and Sous Vide. I have an Anova steam oven that also does Sous Vide without the vacuum bagging.